Notes

Sulfonamides

Sulfonamides

Sulfonamides are bacteriostatic antibiotics. They include: Sulfamethoxazole (Mostly combined with trimethoprim) Sulfadiazine Sulfisoxazole Sulfasalazine Balsalazide Pregnancy Category: C (and D at term) They can be used in life-threatening conditions when there are no safer drugs. Studies have shown that they have potential risks to fetal life. They may increase the levels of unconjugated bilirubin and […]

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Tetracyclines

Tetracyclines

Tetracyclines are bacteriostatic antibiotics. They include; Tetracycline Doxycycline Demeclocycline Minocycline Pregnancy Category: D Tetracyclines are toxic to the fetus and also cause teeth damage in infants. Mechanism of Action They are bacteriostatic. They prevent the replication of susceptible bacteria cells by inhibiting protein synthesis. Pharmacokinetics Absorption: They are adequately absorbed following oral ingestion. Administration with

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Cephalosporins

Cephalosporins

Cephalosporins are antibiotics that act on the bacterial cell wall. They are structurally and functionally related to penicillins. They are classified into five generations based on their spectrum of action and beta lactamase resistance. These generations include; First Generation; cefazolin, cephalothin, cephalexin, cefadroxil, cephapirin Second Generation; cefuroxime, cefprozil, cefoxitin, cefmetazole, cefaclor, cefoxitin Third Generation; ceftriaxone,

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Penicillins

penicillins

Penicillins are the most commonly known antibiotic drugs. They are generally effective and have fewer toxic properties and thus tend to be overused. Their frequent use has promoted antimicrobial resistance, making scientists develop stronger combinations. Penicillins include; Amoxicillin Ampicillin Penicillin G Penicillin V Piperacillin Tircacillin There are bacteria of the genus Staphylococci that produce beta-lactamase

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Aminoglycosides

Aminoglycosides are antibiotics (they exert their effects against bacteria). The term aminoglycoside is derived from its structure; two amino sugars linked to a central hexose nucleus by a glycoside. Drugs in this antibiotics class include: • Amikacin • Gentamycin • Neomycin • Streptomycin • Tobramycin • Kanamycin • Paromomycin • Plazomicin Pregnancy Category: D It

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